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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EP300
All Species:
45.76
Human Site:
Y1483
Identified Species:
83.89
UniProt:
Q09472
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q09472
NP_001420.2
2414
264161
Y1483
S
E
R
I
V
H
D
Y
K
D
I
F
K
Q
A
Chimpanzee
Pan troglodytes
XP_515155
2411
263753
Y1483
S
E
R
I
V
H
D
Y
K
D
I
F
K
Q
A
Rhesus Macaque
Macaca mulatta
XP_001102844
2414
264251
Y1483
S
E
R
I
V
H
D
Y
K
D
I
F
K
Q
A
Dog
Lupus familis
XP_851777
2404
260682
Y1484
A
E
R
I
I
H
D
Y
K
D
I
F
K
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
P45481
2441
265456
Y1520
A
E
R
I
I
N
D
Y
K
D
I
F
K
Q
A
Rat
Rattus norvegicus
XP_001076610
2413
263563
Y1481
S
E
R
I
V
H
D
Y
K
D
I
L
K
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233888
2444
267496
Y1497
S
E
R
I
V
H
D
Y
K
D
I
F
K
Q
A
Frog
Xenopus laevis
NP_001088637
2428
264402
Y1510
A
E
R
I
I
H
D
Y
K
D
I
F
K
Q
A
Zebra Danio
Brachydanio rerio
XP_001332718
2667
289125
Y1492
A
E
R
V
V
H
D
Y
K
D
I
F
K
Q
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524642
3276
340709
Y2140
I
E
R
I
I
Q
D
Y
K
D
I
L
K
Q
A
Honey Bee
Apis mellifera
XP_001122031
2606
284119
Y1719
V
E
R
I
V
L
D
Y
K
D
I
L
K
Q
A
Nematode Worm
Caenorhab. elegans
P34545
2056
227161
K1286
P
P
E
Q
K
I
P
K
P
K
R
L
Q
D
W
Sea Urchin
Strong. purpuratus
XP_782558
2635
288594
Y1727
G
D
G
V
I
N
I
Y
N
D
I
M
N
A
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.2
61
N.A.
58.6
94.1
N.A.
N.A.
85.1
60.4
57
N.A.
36.2
43
31.1
39.5
Protein Similarity:
100
99.7
99.5
72.4
N.A.
69.5
96.1
N.A.
N.A.
89.9
71
65.9
N.A.
46.6
54.9
45.6
51.5
P-Site Identity:
100
100
100
86.6
N.A.
80
93.3
N.A.
N.A.
100
86.6
86.6
N.A.
73.3
80
0
26.6
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
100
100
100
N.A.
80
80
6.6
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
31
0
0
0
0
0
0
0
0
0
0
0
0
8
93
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
85
0
0
93
0
0
0
8
0
% D
% Glu:
0
85
8
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
62
0
0
0
% F
% Gly:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
62
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
77
39
8
8
0
0
0
93
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
8
85
8
0
0
85
0
0
% K
% Leu:
0
0
0
0
0
8
0
0
0
0
0
31
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
16
0
0
8
0
0
0
8
0
0
% N
% Pro:
8
8
0
0
0
0
8
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
8
0
0
0
0
0
0
8
85
0
% Q
% Arg:
0
0
85
0
0
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
39
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
8
0
0
16
54
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _